12 replies to this topic

[skeaman]

Ido not know if any one has come across this site Cure it might be possible look up www.neuroglemmarche .org check out wesite click British flag i know money is hard to get But we also know it is a lot harder sitting in a wheelchair .Yearly membership 20 euro's For that kind of money why not . Think of the biger picture you can gave more as a Donation

[skeaman]

skeaman, on Jan 6 2009, 03:07 PM, said:

Ido not know if any one has come across this site Cure it might be possible look up www.neuroglemmarche .org check out wesite click British flag i know money is hard to get But we also know it is a lot harder sitting in a wheelchair .Yearly membership 20 euro's For that kind of money why not . Think of the biger picture you can gave more as a Donation

some months ago i donated some money and joined them this is a video of what work they are doing i know their is a lot of work to do but it is a start and it bring us hope so if we keep donating we will get their


http://www.dailymoti...jDjeQAu4cd1iFZj

[skeaman]

skeaman, on Dec 12 2009, 01:19 PM, said:

skeaman, on Jan 6 2009, 03:07 PM, said:

Ido not know if any one has come across this site Cure it might be possible look up www.neuroglemmarche .org check out wesite click British flag i know money is hard to get But we also know it is a lot harder sitting in a wheelchair .Yearly membership 20 euro's For that kind of money why not . Think of the biger picture you can gave more as a Donation

some months ago i donated some money and joined them this is a video of what work they are doing i know their is a lot of work to do but it is a start and it bring us hope so if we keep donating we will get their


http://www.dailymoti...jDjeQAu4cd1iFZj

well can any one tell me what you's think of it and has any one donated ? i know it will come down to money but we have to try some thing put it this way if it works it will be for every body

[topperf]

Neurogel is the apparently the real deal - if we want a cure, we are going to have to make it happen ourselves, I haven't donated to Neurogel yet, but I'm supporting others.. (I will see if I can find some money for these guys, they are getting us there too)
And if I was living in Portugal, I would be head over heals to get a hold of the Portuguese doc in the video..

[skeaman]

thanks for that these doc are experts in there field so we hope some thing comes out of it

Edited by skeaman, 06 January 2010 - 07:47 PM.

[sean3282]

Like Topper I have also heard of the org but haven't donated as the thermometer icon for projected target donations required to carry out the clinical trials is full, so by that I think they have the funding needed. I have donated to others but will also give to Neurogel what I can. Lets hope all the intended trials scheduled for 2010 go ahead and show promise.

[sean3282]

Scientists successfully treat rats' injured spinal cords.

Prague, Feb 1 (CTK) - Czech scientists have succeeded in treating spinal cord chronic injuries in rats and want to start testing hydrogel with stem cells in people as soon as possible, Eva Sykova, from Science Academy Experimental Medicine Institute, told CTK yesterday.
The experiment is financially supported by the French Association of Patients. French and Spanish patients are to participate in the clinical study of the new method.
People with an injured spinal cord often end up in a wheelchair and the new method is a hope for them.
If a hydrogel with stem cells was inserted in the place of an injury in a rat's spinal cord, new nerve fibres were created and the mobility and sensitiveness of its hind legs improved within half a year.
"We expect the hydrogel with stem cells to be approved for clinical testing within a year and we will then immediately start checking it in people," Sykova said.
She said the method will be applicable to injuries old even several years.
"It has shown that neither cell stems alone nor hydrogels alone are sufficiently effective. Combination of minimally the two things, and in the future also probably of further factors is necessary," Sykova said.

Prague Daily Monitor

[skeaman]

sean3282, on Feb 2 2010, 10:26 AM, said:

Scientists successfully treat rats' injured spinal cords.

Prague, Feb 1 (CTK) - Czech scientists have succeeded in treating spinal cord chronic injuries in rats and want to start testing hydrogel with stem cells in people as soon as possible, Eva Sykova, from Science Academy Experimental Medicine Institute, told CTK yesterday.
The experiment is financially supported by the French Association of Patients. French and Spanish patients are to participate in the clinical study of the new method.
People with an injured spinal cord often end up in a wheelchair and the new method is a hope for them.
If a hydrogel with stem cells was inserted in the place of an injury in a rat's spinal cord, new nerve fibres were created and the mobility and sensitiveness of its hind legs improved within half a year.
"We expect the hydrogel with stem cells to be approved for clinical testing within a year and we will then immediately start checking it in people," Sykova said.
She said the method will be applicable to injuries old even several years.
"It has shown that neither cell stems alone nor hydrogels alone are sufficiently effective. Combination of minimally the two things, and in the future also probably of further factors is necessary," Sykova said.

Prague Daily Monitor

sean3282
thank you for putting on it looks good hopefully things will start soon it looks like we are the only ones that have commented on the work they are doing
WE CAN STILE DONATE FOR IF SOME THING COMES OF IT WE ALL CAN GET USE OF IT
P S DON'T SHOOT THE MESSENGER

Edited by skeaman, 02 February 2010 - 06:58 PM.

[sean3282]

Hi Skeaman, also read the following on another SCI forum, which shows that things are slowly moving forward and there is a reason to hope that one day we may be out of these damn chairs. But until then life rolls on.


" Michael Fehlings et al. have a study in tomorrow's Journal of Neuroscience reporting that the combination of chondroitinase, two three growth factors, and NPCs restores greater function than NPCs alone. It also shows that the functional restoration occured without a corresponding increase in neuropathic pain.

I find this exciting because a) it justifies the use of combination therapies in humans, it's the beginning of [what I suspect will be] a string of results of various combination therapies, and c) it shows that the various SCINets will have a validated pipeline of combinations to choose from for human application.

From the paper's intro:

Quote:
Repair of the chronically injured spinal cord is inherently challenging due to multiple factors, including cellular loss, a cystic cavity that disrupts axonal pathways, and the inhibitory influence of the glial scar (Silver and Miller, 2004; Thuret et al., 2006). Therefore, treatment of chronic spinal cord injury (SCI) will require a multifaceted strategy. To date, no successful functional treatment for contusive chronic SCI has been achieved. . . .

Here, in a chronic model of compressive SCI in rodents, we disturbed CSPGs with intrathecal infusion of chondroitinase ABC (ChABC) for 7 d. Then, we transplanted the same chronically injured rats with NPCs and transiently supplemented the spinal cord with the intrathecal infusion of a GF cocktail containing epidermal growth factors (EGF), fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF-AA). We provide strong evidence that this combinatorial approach markedly increases the long-term survival of NPCs and greatly optimizes their migration and integration in the chronically injured spinal cord. Furthermore, we demonstrate multiple mechanisms by which this combinatorial strategy facilitates neuroanatomical plasticity of the chronically injured spinal with improved locomotor recovery and without promoting aberrant plasticity of spinal cord pain pathways or exacerbating posttraumatic neuropathic pain.
This is exciting. Not just this specific study, but the trajectory of the SCI research field is exciting.

This study is only the beginning. Within two years (by 1/1/2012), I'm confident that at least one combination therapy that includes neuron replacement will prove effective in animal models. By the end of 2012 (i.e., 12/31/2012), I'm confident that at least one combination therapy will bring significant functional return in humans.

This will happen.

Support your local scientists.

Support your local SCINet".

Fingers crossed all.

Sean

[skeaman]

sean3282, on Feb 3 2010, 02:52 PM, said:

Hi Skeaman, also read the following on another SCI forum, which shows that things are slowly moving forward and there is a reason to hope that one day we may be out of these damn chairs. But until then life rolls on.


" Michael Fehlings et al. have a study in tomorrow's Journal of Neuroscience reporting that the combination of chondroitinase, two three growth factors, and NPCs restores greater function than NPCs alone. It also shows that the functional restoration occured without a corresponding increase in neuropathic pain.

I find this exciting because a) it justifies the use of combination therapies in humans, it's the beginning of [what I suspect will be] a string of results of various combination therapies, and c) it shows that the various SCINets will have a validated pipeline of combinations to choose from for human application.

From the paper's intro:

Quote:
Repair of the chronically injured spinal cord is inherently challenging due to multiple factors, including cellular loss, a cystic cavity that disrupts axonal pathways, and the inhibitory influence of the glial scar (Silver and Miller, 2004; Thuret et al., 2006). Therefore, treatment of chronic spinal cord injury (SCI) will require a multifaceted strategy. To date, no successful functional treatment for contusive chronic SCI has been achieved. . . .

Here, in a chronic model of compressive SCI in rodents, we disturbed CSPGs with intrathecal infusion of chondroitinase ABC (ChABC) for 7 d. Then, we transplanted the same chronically injured rats with NPCs and transiently supplemented the spinal cord with the intrathecal infusion of a GF cocktail containing epidermal growth factors (EGF), fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF-AA). We provide strong evidence that this combinatorial approach markedly increases the long-term survival of NPCs and greatly optimizes their migration and integration in the chronically injured spinal cord. Furthermore, we demonstrate multiple mechanisms by which this combinatorial strategy facilitates neuroanatomical plasticity of the chronically injured spinal with improved locomotor recovery and without promoting aberrant plasticity of spinal cord pain pathways or exacerbating posttraumatic neuropathic pain.
This is exciting. Not just this specific study, but the trajectory of the SCI research field is exciting.

This study is only the beginning. Within two years (by 1/1/2012), I'm confident that at least one combination therapy that includes neuron replacement will prove effective in animal models. By the end of 2012 (i.e., 12/31/2012), I'm confident that at least one combination therapy will bring significant functional return in humans.

This will happen.

Support your local scientists.

Support your local SCINet".

Fingers crossed all.

Sean

sean thanks for that and keeping us informed if any new posts come out can you post them on

Edited by skeaman, 04 February 2010 - 02:01 PM.

[skeaman]

sean3282, on Feb 2 2010, 10:26 AM, said:

Scientists successfully treat rats' injured spinal cords.

Prague, Feb 1 (CTK) - Czech scientists have succeeded in treating spinal cord chronic injuries in rats and want to start testing hydrogel with stem cells in people as soon as possible, Eva Sykova, from Science Academy Experimental Medicine Institute, told CTK yesterday.
The experiment is financially supported by the French Association of Patients. French and Spanish patients are to participate in the clinical study of the new method.
People with an injured spinal cord often end up in a wheelchair and the new method is a hope for them.
If a hydrogel with stem cells was inserted in the place of an injury in a rat's spinal cord, new nerve fibres were created and the mobility and sensitiveness of its hind legs improved within half a year.
"We expect the hydrogel with stem cells to be approved for clinical testing within a year and we will then immediately start checking it in people," Sykova said.
She said the method will be applicable to injuries old even several years.
"It has shown that neither cell stems alone nor hydrogels alone are sufficiently effective. Combination of minimally the two things, and in the future also probably of further factors is necessary," Sykova said.

Prague Daily Monitor

This is the link praque thay are working with neurogel
http://praguemonitor...-injured-spines

[E-DOG]

sean3282, on Feb 2 2010, 02:26 AM, said:

Scientists successfully treat rats' injured spinal cords.
Prague Daily Monitor

Quick, somebody call rat-boy!

[skeaman]

skeaman, on 06 January 2009 - 03:07 PM, said:

I do not know if any one has come across this Cure it might be possible look up www.neuroglemmarche .org check out wesite click British flag i know money is hard to get But we also know it is a lot harder sitting in a wheelchair .Yearly membership 20 euro's For that kind of money why not . Think of the bigger picture you can gave more as a Donation

HI GUYS
you may not know but here is the link to these 3 sites
http://spinalnews.or...-4FXKZ-1/c.aspx
http://justadollarplease.org/
http://www.neurogelenmarche.org/
It is a great way to get Donations I have copied and pasted on my own e-mail . So we can only hope when i send a private e-mail It just might trig er some one to gave ? or think a bout it . We can only hope some good comes out of it. I know it will

Edited by skeaman, 26 December 2010 - 11:18 PM.