22 replies to this topic

[dexter]

This is brand-new news. Just posted today!

Boy, our new president is hard at work already!

http://news.yahoo.co...NZBhTB.byAPLBIF

Edited by dexter, 23 January 2009 - 07:14 PM.

[chefzapp]

No offense but did u read the whole article? President Barack Obama has promised to relax the Bush administration's restrictions on federal financing for such research. But Obama's ascent to the White House had nothing to do with the U.S. Food and Drug Administration's granting permission for the new study, Okarma said in a telephone interview Thursday.
In fact, the company says, the project involves stem cells that were eligible for federal funding under Bush, although no federal money was used to develop the experimental treatment or to pay for the human study.
I wasn't for Bush and watch out for Obama being a wolf in sheep's clothing. Don't be lead blindly by the media and your heart. The lesser of two evils is still evil!

[dexter]

chefzapp, on Jan 23 2009, 11:14 AM, said:

I wasn't for Bush and watch out for Obama being a wolf in sheep's clothing. Don't be lead blindly by the media and your heart. The lesser of two evils is still evil!

Haha, you're too funny. A bit bitter but still funny.

[Hikkakaru]

and in California. Woot.

But yeah, has nothing to do with our new president.

[chefzapp]

U changed your post????? Only took a few minutes, U don't love him anymore? He still had nothing to do with it as the article expressed. Bitter, nah.

[dexter]

chefzapp, on Jan 23 2009, 11:28 AM, said:

U changed your post????? Only took a few minutes, U don't love him anymore? He still had nothing to do with it as the article expressed. Bitter, nah.

No, the post is still same.



Our new president is the one who is putting money into stem cell research. It just might be an amazing cure for people with Spinal Cord Injuries.

[chefzapp]

Really no change????? Like Obama CHANGE, This post has been edited by Dexter Today 7:14.pm?????????? U said U already loved our new president in the original hmmmmmmmmm? The wool is not pulled over my eyes quite so easily!!! Read the article this was already in place!

[Hikkakaru]

chefzapp, on Jan 23 2009, 11:48 AM, said:

Really no change????? Like Obama CHANGE, This post has been edited by Dexter Today 7:14.pm?????????? U said U already loved our new president in the original hmmmmmmmmm? The wool is not pulled over my eyes quite so easily!!! Read the article this was already in place!

God can you shut up with the 'U's?

This thread isn't about politics, this thread is about the amazing future technologies and cures that the U.S. just officially joined in making possible and the fact that it has endless possibilities for the spinal-cord injury afflicted population.

Edited by Hikkakaru, 23 January 2009 - 07:56 PM.

[Yong]

chefzapp, on Jan 23 2009, 02:48 PM, said:

Really no change????? Like Obama CHANGE, This post has been edited by Dexter Today 7:14.pm?????????? U said U already loved our new president in the original hmmmmmmmmm? The wool is not pulled over my eyes quite so easily!!! Read the article this was already in place!

FAIL.

[chefzapp]

God can you shut up with the 'U's?

This thread isn't about politics, this thread is about the amazing future technologies and cures that the U.S. just officially joined in making possible and the fact that it has endless possibilities for the spinal-cord injury afflicted population. UUU got it buddy! I seem to be misunderstood, I am for it. I was responding to his first post which is now gone but apparently was never there in the first place. Im sorry!!! This is 1 reason why I posted at all, related article same subject matter. Okarma said there was no political significance to the announcement coming the same week as President Barack Obama took office. Obama has been widely expected to lift restrictions on federal funding and support of human embryonic stem cell research. I was trying to take the politics out of it! Again sorry I will crawl into my hole and shut up now.

Edited by chefzapp, 23 January 2009 - 09:14 PM.

[E-DOG]

HEY!
I'm tryin' to get some research done here!

How am I suppose to dissect the neighbor's Rottweiler with you guys arguing all the time?
Oh yeah, got that sucker yesterday. Lured him over with a French Poodle I had layin' around here.

E-dog / researchin' a dang cure fer us what cain't walk no mo'.

[Doug]

Well fingers crossed they get results but 2 weeks post seems sketchy to me. They should test both new and old injuries quads and paras. Dont get me wrong I am 100% for any research that can help anyone with an SCI in any way!!! Im just impatient I guess....They should have had a green light to test years ago...but a late start is better then no start

[Kev-O]

chefzapp, on Jan 23 2009, 03:49 PM, said:

God can you shut up with the 'U's?

This thread isn't about politics, this thread is about the amazing future technologies and cures that the U.S. just officially joined in making possible and the fact that it has endless possibilities for the spinal-cord injury afflicted population. UUU got it buddy! I seem to be misunderstood, I am for it. I was responding to his first post which is now gone but apparently was never there in the first place. Im sorry!!! This is 1 reason why I posted at all, related article same subject matter. Okarma said there was no political significance to the announcement coming the same week as President Barack Obama took office. Obama has been widely expected to lift restrictions on federal funding and support of human embryonic stem cell research. I was trying to take the politics out of it! Again sorry I will crawl into my hole and shut up now.

Man those liberals sure do get pissed when you say something bad about "Superman".


Just thought i would throw that little dig in there.

Edited by Kev-O, 23 January 2009 - 11:36 PM.

[Texaswheelz]

Doug, on Jan 23 2009, 05:37 PM, said:

Well fingers crossed they get results but 2 weeks post seems sketchy to me. They should test both new and old injuries quads and paras. Dont get me wrong I am 100% for any research that can help anyone with an SCI in any way!!! Im just impatient I guess....They should have had a green light to test years ago...but a late start is better then no start

I completely agree and it was the first thing I thought of. If the test subject starts to get something back, how exactly are they going to know if it was from the cells or if is something they might have been getting back anyway. I think they should start at the 2 or 3 years mark as that is when most returns stop coming.

[airart1]

there suppose to be under supervision and rehab for one year, the ones that are new injury, the freezing thing made a big difference to that one player also, hope, for the future, it's been along time since i thought that way..........it wont help me but it might keep future from this horrible thing..............

[Apparelyzed]

Texaswheelz, on Jan 24 2009, 03:51 AM, said:

If the test subject starts to get something back, how exactly are they going to know if it was from the cells or if is something they might have been getting back anyway. I think they should start at the 2 or 3 years mark as that is when most returns stop coming.

Because .....

The selected patients eligible for the Phase I trial must have documented evidence of functionally complete spinal cord injury with a neurological level of T3 to T10 spinal segments and agree to have GRNOPC1 injected into the lesion sites between seven and 14 days after injury.

If the cells are administered sooner, they could be damaged by inflammation from the injury. If doctors wait too long, there might be too much scar tissue for the cells to find room to grow.

Regards

Simon

[Apparelyzed]

In addition to the above, from Geron:

hESC-Derived Oligodendrocytes - GRNOPC1

Embryonic stem cell-derived neural cells have been used by researchers to treat nervous system disorders in animal models. In the case of spinal cord injuries, neural cells derived from animal embryonic stem cells and injected into the spinal cord injury site produced significant recovery of the animal's ability to move and bear weight.

To apply those observations to humans, we have now derived oligodendroglial progenitor cells (GRNOPC1) from hESCs in culture and tested them in a rat model of spinal cord injury. In our collaboration with researchers at the University of California, Irvine, we have shown in animal models that GRNOPC1 can improve functional locomotor behavior after implantation in the injury site 7 days after injury. Histological analysis also provided evidence for the engraftment and function of these cells. These data were published in May 2005 in the Journal of Neuroscience. We have developed functional cryopreserved formulations of GRNOPC1 that can be readily implemented in clinical trials and have initiated cGMP production of GRNOPC1. We have completed IND-enabling studies for hESC-derived oligodendrocytes for application in spinal cord injury. We have received FDA clearance to begin the world's first human clinical trial of an embryonic stem cell-based therapy using GRNOPC1.

Once safety in this patient population has been established and the FDA reviews clinical data in conjunction with additional data from ongoing animal studies, Geron plans to seek FDA approval to extend the study to increase the dose of GRNOPC1, enroll subjects with complete cervical injuries and expand the trial to include patients with severe incomplete (ASIA grade B or C) injuries to enable access to the therapy for as broad a population of severe spinal cord-injured patients as is medically appropriate.

[Kev-O]

Apparelyzed, on Jan 24 2009, 11:36 AM, said:

Texaswheelz, on Jan 24 2009, 03:51 AM, said:

If the test subject starts to get something back, how exactly are they going to know if it was from the cells or if is something they might have been getting back anyway. I think they should start at the 2 or 3 years mark as that is when most returns stop coming.

Because .....

The selected patients eligible for the Phase I trial must have documented evidence of functionally complete spinal cord injury with a neurological level of T3 to T10 spinal segments and agree to have GRNOPC1 injected into the lesion sites between seven and 14 days after injury.

If the cells are administered sooner, they could be damaged by inflammation from the injury. If doctors wait too long, there might be too much scar tissue for the cells to find room to grow.

Regards

Simon

I dont know if this is just wishful thinking but couldn't they just cut out the scar tissue an to expose the fresh cord then plant the cells?

[Apparelyzed]

Kev-O, on Jan 24 2009, 04:51 PM, said:

I dont know if this is just wishful thinking but couldn't they just cut out the scar tissue an to expose the fresh cord then plant the cells?

Not in clinical trials, and not at such an early stage of seeing if ESC actually works.

Cutting out scar tissue would be a destructive procedure, and the scar tissue would have to be identified exactly before any procedure could be undertaken. Also, what if there was a one inch section of the cord which was scared, you cut it out, what you going to replace it with?

It would be better if some sort of combination therapy was devised, with a solution to dissolve the scar tissue, whist the ESC's worked with growth promotors to grow and myelinate axons.

Simon.

[love&hate]

I could see that coming and I'm not really surprised. On the other hand I'm very happy every time i read something about people working hard in order to help others that need it. I have been following all kinds of medical studies i could find on the internet and this one made my day. It gives me hope and hope is something I really need. I think we all do. I truly believe it is only a matter of time. People can say what they want. For me the glass will always be half full not half empty.

@chefzapp -- Please take this political bs out of this thread. We dont wanna see it here.

[Kev-O]

love&hate, on Jan 24 2009, 02:47 PM, said:

@chefzapp -- Please take this political bs out of this thread. We dont wanna see it here.

He didn't start it. He was just pointing out a fact.

[love&hate]

Kev-O, on Jan 24 2009, 03:00 PM, said:

love&hate, on Jan 24 2009, 02:47 PM, said:

@chefzapp -- Please take this political bs out of this thread. We dont wanna see it here.

He didn't start it. He was just pointing out a fact.

Clearly the OP was excited about the new information he found on the internet and wanted to share with us asap. chefzapp after pointing out his mistake began his political attack. We dont wanna see it here.

[AndrewB]

OK, I think liberals and Conservatives alike can mostly agree that George w bush was a complete idiot and doesn't know a stem cell from a jail cell, or what a cell even is. but thats not the point here, the point is everyone seems to be crediting barack obama with this, and it clearly didn't have anything to do with him, it had to do with a private reasearch company getting a green light from the FDA.