5 replies to this topic

[McCann]

This post pertains to all other posts in this forum and to the general idea of most (not all) SCI injuries, not individuals (each individual conducts his/her life in various manners that may affect healthwise positively or negatively). The other posts should be read for full/better understanding of what is written in this post. This is a culmination of the research, posts, and info.
Everyone/most (hopefully) know what the wire/cord that current or electricity looks like and/or how it’s made up. It is best generally explained as the wire being surrounded or insulated by a rubber-like material. That coating keeps the wire’s electrical signal and allows it to travel on a clear pathway and allows electricity to travel from outlet to object/appliance. This travel of electricity is an analogy to the way signals travel in regarding axons and messages sent to extremities. In an undamaged or normal state the myelin located around the axon protects the electrical signal and at the same time keeps a clean or undisturbed channel/canal or pathway for the signal from the CNS to travel to the extremities.
At times, the wire/cord has a short when the coating is damaged (eroded or missing). It can lead to electricity not traveling properly due to the wire/cord’s ‘exposure.’ The electricity can short and travel to other places. There is similarity when the analogy is made to axons and the traveling of its signals. When fluids permeate the myelin, the signal from the CNS dissipates to other regions and causes varying degrees of paralysis. Then the question to ask is “what strategy” can restore impulse conduction along demyelinated axons and functional recovery?
Here's a site with some reading material and it'd be interesting to see/hear what Dr. Wise Young vs Dr. Stephen G.Waxman say/think regarding their finds, theories and so forth.
http://www.destinati...earchnotes.html

Edited by McCann, 01 July 2009 - 11:37 PM.

[edlee]

That is, undoubtedly, a very important question,,, and one that is being asked through several clinical studies now ongoing as well as a number already completed.

Please understand, McMann, that you aren't speaking to those unfamiliar with the condition. Most , here, have had long history with the terminology. There is no need to wind up before the pitch.
ed

[McCann]

edlee, on Jul 1 2009, 03:15 PM, said:

That is, undoubtedly, a very important question,,, and one that is being asked through several clinical studies now ongoing as well as a number already completed.

Please understand, McMann, that you aren't speaking to those unfamiliar with the condition. Most , here, have had long history with the terminology. There is no need to wind up before the pitch.
ed

Regarding the "wind-up," what about those that don't know as much as you or others? The idea of a wind up isn't intentional, it's only to avoid assuming things are known by the reader.

[edlee]

Assume away, my friend,,, if anyone is in doubt, they will ask.

I checked out your link, but other than a testimonial for the credentials of Dr. Waxman, there was not much to see. Destination Cure may well be a good organization,,, but I'll donate to those closer to home, since I'm limited in my generosity due to my income level.

To my knowledge,, which I admit is limited,, all of the clinical studies dealing with restoring the myeline on axons,, has been pharmacalogically driven. And to date, have not reached human testing.

Part of the promise of stem cell research is in the same realm. Remyelination and peripheral nerve generation/regeneration seem to hold more promise for shorter term success,,,, but that may be wishful thinking on my part, since the researchers are very vague about expected results,,,, unless they are looking for grant money.

ed

[McCann]

edlee, on Jul 3 2009, 12:13 AM, said:

Assume away, my friend,,, if anyone is in doubt, they will ask.

I checked out your link, but other than a testimonial for the credentials of Dr. Waxman, there was not much to see. Destination Cure may well be a good organization,,, but I'll donate to those closer to home, since I'm limited in my generosity due to my income level.

To my knowledge,, which I admit is limited,, all of the clinical studies dealing with restoring the myeline on axons,, has been pharmacalogically driven. And to date, have not reached human testing.

Part of the promise of stem cell research is in the same realm. Remyelination and peripheral nerve generation/regeneration seem to hold more promise for shorter term success,,,, but that may be wishful thinking on my part, since the researchers are very vague about expected results,,,, unless they are looking for grant money.

ed

I'm glad that his credentials are realized/seen. Now the question of importance is/was “what strategy” can restore impulse conduction along demyelinated axons and functional recovery?
One answer is xxxxxxxx & its (xxxxxxxx specific) Treatment Program or some AC current operated NMES of the same or better electrical parameters. I will post a write up explaining in several hours.

[Apparelyzed]

McCann,

Please respect the request made on June 19th here : http://www.apparelyz...h...st&p=115511

Regards

Simon