Quadriplegic & Paraplegic Spinal Cord Injuries: Tylenol Is Bad For Spinal Cord Injuries - Quadriplegic & Paraplegic Spinal Cord Injuries

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Tylenol Is Bad For Spinal Cord Injuries Rate Topic: -----

#1 User is offline   saradise 

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Posted 01 November 2009 - 04:39 PM

After reading a post on here, I just wanted to share that a doctor we met while my husband was in the hospital for a year said there is new research showing that Tylenol is very harmful for people with spinal cord injuries. He said studies are showing that Tylenol prevents new stem cells from growing. All I know is that he said to stay away from Tylenol if you have a spinal cord injury!
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#2 User is offline   Apparelyzed 

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Posted 02 November 2009 - 08:43 AM

Hi,

It would help if you could cite the research to back up this claim.

The only reference I can find regarding Tylenol, known as Paracetamol in the UK, generic name Acetaminophen, is in the production of stem cell factors in people with liver damage, not spinal cord injuries.

Here's the reference: Stem Cell Factor Attenuates Liver Damage in a Murine Model of Acetaminophen-Induced Hepatic Injury

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Acute liver injury is a common cause of intensive care unit visits. In these studies, we used a murine model of acetaminophen poisoning to examine the role of stem cell factor (SCF) on liver damage. In the initial studies, we identified that the liver produces relatively high constitutive levels of SCF. Upon administration of acetaminophen, the levels of SCF fell dramatically, correlating to damage within the liver. When the liver was allowed to regenerate, the levels of SCF again correlated with the liver regeneration. We next treated mice with anti-SCF before sublethal doses of acetaminophen and significantly increased lethality in anti-SCF–treated animals. When exogenous SCF was given to mice, the lethality was significantly reduced compared with the control acetaminophen-treated animals and the damage within the liver tissue was attenuated. The administration of rSCF reduced the level of steady-state mRNA for cytochrome P450 cyp2E1 enzyme both in vitro and in vivo. These data suggest that SCF functions as an important factor that protects livers from acute damage.


Regards

Simon
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